What’s the Mtrr with Your Grandparents?

Summary

“The importance of maternal folate consumption for normal development is well established, yet the molecular mechanism linking folate metabolism to development remains poorly understood. The enzyme methionine synthase reductase (Mtrr) is necessary for utilization of methyl groups from the folate cycle. We found that a hypomorphic mutation of the mouse Mtrr gene results in intrauterine growth restriction, developmental delay, and congenital malformations, including neural tube, heart, and placental defects. Importantly, these defects were dependent upon the Mtrr genotypes of the maternal grandparents. Furthermore, we observed widespread epigenetic instability associated with altered gene expression in the placentas of wild-type grandprogeny of Mtrr-deficient maternal grandparents. Embryo transfer experiments revealed that Mtrr deficiency in mice lead to two distinct, separable phenotypes: adverse effects on their wild-type daughters’ uterine environment, leading to growth defects in wild-type grandprogeny, and the appearance of congenital malformations independent of maternal environment that persist for five generations, likely through transgenerational epigenetic inheritance.”

The research published in the CELL – Volume 155, Issue 1, 26 September 2013 (Pages 81–93) : “Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development” carried out by,

indicates that,

  • Mutation in the Mtrr gene causes abnormal folate metabolism in mice
  • Mtrr genotype of maternal grandparent affects development of wild-type grandprogeny
  • Placentas of wild-type grandprogeny display widespread epigenetic instability
  • Mtrr mutation impacts both the in utero environment and epigenetic inheritance
The homocysteine and folates metabolic pathway. The enzymes encoded by genes investigated in the present study are indicated. MTHFR: methylenetetrahydrofolate reductase; MTRR: methionine synthase reductase; MTR: methionine synthase; CBS: cystathionine-beta-synthase; RFC1: reduced folate carrier 1; MTHFD: methylenetetrahydrofolate dehydrogenase; B12: vitamin B12; B2: vitamin B2; B6: vitamin B6.

The homocysteine and folates metabolic pathway. The enzymes encoded by genes investigated in the present study are indicated. MTHFR: methylenetetrahydrofolate reductase; MTRR: methionine synthase reductase; MTR: methionine synthase; CBS: cystathionine-beta-synthase; RFC1: reduced folate carrier 1; MTHFD: methylenetetrahydrofolate dehydrogenase; B12: vitamin B12; B2: vitamin B2; B6: vitamin B6. (NOT MY PROPERTY)

Share a thought!

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s